Journal article
Global, asynchronous partial sweeps at multiple insecticide resistance genes in Aedes mosquitoes
TL Schmidt, NM Endersby-Harshman, ARJ van Rooyen, M Katusele, R Vinit, LJ Robinson, M Laman, S Karl, AA Hoffmann
Nature Communications | Published : 2024
Abstract
Aedes aegypti (yellow fever mosquito) and Ae. albopictus (Asian tiger mosquito) are globally invasive pests that confer the world’s dengue burden. Insecticide-based management has led to the evolution of insecticide resistance in both species, though the genetic architecture and geographical spread of resistance remains incompletely understood. This study investigates partial selective sweeps at resistance genes on two chromosomes and characterises their spread across populations. Sweeps at the voltage-sensitive sodium channel (VSSC) gene on chromosome 3 correspond to one resistance-associated nucleotide substitution in Ae. albopictus and three in Ae. aegypti, including two substitutions at ..
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Grants
Awarded by Department of Foreign Affairs and Trade, Ireland
Funding Acknowledgements
We acknowledge the efforts of Jiannong Xu, Esther Anderson, Scott Ritchie, and Siaola Mahe for mosquito collections and shipments. We thank Frank Jiggins, Gabriela Montejo-Kovacevich, and Henry North for useful early discussions on analysis. We acknowledge the efforts of the PNGIMR entomology team, especially Samuel Demok, Peter Kaman, and Joelyn Goi, as well as the PNGIMR LF team for their assistance with mosquito collections and shipments. We acknowledge the support of Tim Freeman and RAM team for work conducted in National Capital District, Papua New Guinea. We acknowledge the support of Leo Makita for samples collected during malaria control surveys. We acknowledge PNG Provincial Health Authorities in East New Britain, New Ireland, East Sepik, West Sepik, Morobe, Madang, Milne Bay, Western and National Capital District for their collaboration and support. We acknowledge the efforts of the STRIVE PNG Partnership Project Managers Annie Dori and Rachael Farquhar for the coordination they facilitate across multiple organisations to support the implementation of activities under the leadership of the PNG National Malaria Control Programme. Sampling and sequencing of Papua New Guinea was funded by STRIVE PNG through the Department of Foreign Affairs and Trade, Australian Government [Grant No. 74430], Indo-Pacific Centre for Health Security. T.L.S. was funded by an ARC DECRA Fellowship (DE230100257). L.J.R. was funded by a NHMRC Career Development Fellowship (GNT1161627). SK was funded by NHMRC Development Grant (GNT1141441) and NHMRC Ideas Grant (2004390).